Authors (including presenting author) :
Chan HK (1)(2), Sin SL(1)(2)
Affiliation :
(1)Pharmacy department, Queen Elizabeth Hospital
(2)School of Pharmacy, The Chinese University of Hong Kong
Introduction :
Currently there is not any validated Chinese version oral anticoagulant
knowledge tool that is applicable to both warfarin and DOACs, this tool will be developed and validated in this study and aim to be widely used in routine clinical settings
Objectives :
To develop and validate a Chinese oral anticoagulant knowledge tool that is
applicable to all oral anticoagulant medications.
Methodology :
Design: This is a prospective validation study. It included developing a knowledge tool and assessing its validity and reliability. A pilot study and a main study are included in this project.
Setting: This study recruits patient groups in a single centre (Queen Elizabeth Hospital), while subjects from pharmacist group and general public group are recruited in Hong Kong.
Participants: There are a total number of 200 participants in our study. They are further divided into 3 groups: 100 patients, 50 pharmacists, and 50 members of the general public. Among patient groups, 50 of them are taking warfarin and 50 of them are taking direct oral anticoagulants (DOACs). The sampling method of patients is stratified sampling. The recruitment of samples in pharmacists and general public groups is by random sampling.
Result & Outcome :
Results: The 19-item knowledge tool had been developed with a scale content validity index of 0.95. The mean score of the pharmacist group was significantly higher than that of the patient group, and the patient group scored significantly higher than that of the general public (90.0% vs 51.5% vs 19.0%, respectively, p<0.001).
Also, Cronbach’s alpha of 0.86 was achieved. This instrument has successfully passed content validity, construct validity and internal consistency reliability test.
Mean score of patients who attended pharmacist-managed anticoagulant therapy
management clinic (PAC) is higher than that of patients who have never attended PAC
(56.8% vs 46.3%, respectively, p<0.05). No relationship between mean scores and age, education level, and number of years taking oral anticoagulants can be established.
Conclusions: The Chinese version of oral Anticoagulation Knowledge Tool is a valid and reliable instrument that can be used in routine clinical practice to assess patients’ anticoagulation knowledge
